Body & Beauty / Compounds / Quinoxaline

Quinoxaline on your skin: a safety profile

Moderate risk

(People-specific data is limited; this page draws from human adult context.) Quinoxaline — structurally related to quinoline (IARC 2B); used in fragrance formulations; hepatotoxic; limited individual toxicity data

What is quinoxaline?

Also known as: 1,4-Benzodiazine, Benzoparadiazine, Benzopyrazine, Phenopiazine.

IUPAC name
quinoxaline
CAS number
91-19-0
Molecular formula
C8H6N2
Molecular weight
130.15 g/mol
SMILES
C1=CC=C2C(=C1)N=CC=N2
PubChem CID
7045

Risk for people

Moderate risk

Quinoxaline — structurally related to quinoline (IARC 2B); used in fragrance formulations; hepatotoxic; limited individual toxicity data

Regulatory consensus

1 regulatory bodyhas classified Quinoxaline.

AgencyYearClassificationNotes
PROP_652012carcinogenCalifornia Prop 65 — listed as carcinogen

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter quinoxaline

  • Personal Care — fragrance formulations
  • Fragrance — perfume, cologne, scented personal care products, household fragrance products, candles
    Identified in Fragrance Ingredient Safety Priority Research database (2,325 ingredients)

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Quinoxaline:

  • Exposure reduction / process control
    Trade-offs: Requires R&D investment to redesign synthesis routes; may reduce yield or throughput initially; long-term benefits include reduced waste treatment costs, regulatory compliance, and worker safety; 12 Principles of Green Chemistry framework available.
    Relative cost: 1.2-2×

Frequently asked questions

What products contain quinoxaline?

Quinoxaline appears in: fragrance formulations (Personal care); perfume (Fragrance); cologne (Fragrance).

See Quinoxaline in the body app

Look up products containing quinoxaline, compare to alternatives, and explore the full data record.

Open in body View raw API data

Sources (1)
  1. PubChem Compound Database (2026) — database

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →