Lauramidopropyl betaine on your skin: a safety profile

What is lauramidopropyl betaine?

The IUPAC name is 2-[lauroyl(ethyl)amino]acetic acid betaine.

Also known as: 2-[lauroyl(ethyl)amino]acetic acid betaine, LAPB, N-lauroyl-N,N-dimethyl-3-amino-1-propanol.

IUPAC name

2-[lauroyl(ethyl)amino]acetic acid betaine

CAS number

4292-10-8

Molecular formula

C17H36N2O3

Molecular weight

316.49 g/mol

SMILES

C1=C(C(N=N1)C=O)Br

PubChem CID

51401881

Regulatory consensus

1 regulatory bodyhas classified Lauramidopropyl betaine.

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter lauramidopropyl betaine

• baby shampoo
• sensitive skin cleanser
• premium personal care
• specialty shampoo

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Lauramidopropyl betaine:

• Alkyl polyglucosides (APGs) — plant-derived, very mild (e.g., decyl glucoside)
  Trade-offs: Consumer preference for 'natural' label; many natural fragrance compounds are potent allergens (limonene, linalool, eugenol); 'natural' ≠ 'safe'; often more expensive than synthetic equivalents.
  Relative cost: 2-5× conventional
• Amino acid-based surfactants (e.g., sodium lauroyl glutamate, sodium cocoyl glycinate)
  Trade-offs: Extremely mild (pH 5.5-6.5); biodegradable; derived from amino acids and fatty acids; premium ingredient cost; excellent consumer perception; lower foam volume than sulfate surfactants.
  Relative cost: 1.2-2×
• Sodium cocoyl isethionate (SCI) — low irritation potential, solid surfactant
  Trade-offs: Alternative surfactant; performance characteristics (foaming, emulsification, wetting) vary; biodegradability and aquatic toxicity should be assessed; formulation adjustment may be needed.
  Relative cost: 1.2-2×
• Amphoteric surfactants (e.g., cocamidopropyl betaine) — milder than anionic types
  Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
  Relative cost: 1.2-2×

Frequently asked questions