Body & Beauty / Compounds / EDTA (Ethylenediaminetetraacetic acid, free acid)

EDTA (Ethylenediaminetetraacetic acid, free acid) on your skin: a safety profile

Low risk

(People-specific data is limited; this page draws from human adult context.) EDTA (Ethylenediaminetetraacetic acid, free acid) poses low risk to adults under normal use conditions.

What is edta (ethylenediaminetetraacetic acid, free acid)?

The IUPAC name is 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid.

Also known as: EDTA, Edetic acid, Ethylenediaminetetraacetic acid, 60-00-4.

IUPAC name
2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid
CAS number
60-00-4
Molecular formula
C10H16N2O8
Molecular weight
292.24 g/mol
SMILES
C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
PubChem CID
6049

Risk for people

Low risk

EDTA (Ethylenediaminetetraacetic acid, free acid) poses low risk to adults under normal use conditions.

Regulatory consensus

3 regulatory and scientific bodies have classified EDTA (Ethylenediaminetetraacetic acid, free acid). The classifications differ — that's the data.

AgencyYearClassificationNotes
FDA—GRAS as food additive (21 CFR 172.120)
EU—E385 (calcium disodium EDTA); approved food additive
EPA—TSCA listed; no specific restrictions

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter edta (ethylenediaminetetraacetic acid, free acid)

  • Food Preservation — canned beans, salad dressings, mayonnaise, soft drinks
  • Personal Care — shampoo, body wash, hand soap, lotions
  • Cleaning Products — laundry detergent, all-purpose cleaners, dishwasher detergent
  • Medical — chelation therapy IV solutions, blood sample anticoagulant (EDTA tubes)
  • Industrial — boiler water treatment, textile processing, pulp and paper

Safer alternatives

Lower-risk approaches that achieve a similar outcome to EDTA (Ethylenediaminetetraacetic acid, free acid):

  • GLDA (glutamic acid diacetic acid)
    Trade-offs: Direct chemical substitution requires verification that the replacement does not introduce new hazards (regrettable substitution). Conduct full hazard assessment of proposed alternative before adoption.
  • Citric acid
    Trade-offs: Alternative chelating agent; stability constants for target metal ions differ; biodegradability varies (EDTA poorly biodegradable, citrate fully biodegradable); downstream water treatment impact should be assessed.
  • EDDS
    Trade-offs: Direct chemical substitution requires verification that the replacement does not introduce new hazards (regrettable substitution). Conduct full hazard assessment of proposed alternative before adoption.

Frequently asked questions

What products contain edta (ethylenediaminetetraacetic acid, free acid)?

EDTA (Ethylenediaminetetraacetic acid, free acid) appears in: canned beans (food preservation); salad dressings (food preservation); shampoo (personal care); body wash (personal care); laundry detergent (cleaning products).

Why do regulators disagree about edta (ethylenediaminetetraacetic acid, free acid)?

EDTA (Ethylenediaminetetraacetic acid, free acid) has been classified by 3 agencies including FDA, EU, EPA, with differing conclusions. Regulators apply different standards of evidence (animal data weighting, exposure-pattern assumptions, epidemiological power thresholds), which is why two scientific bodies can review the same data and reach different conclusions. See the regulatory consensus table on this page for the full picture.

See EDTA (Ethylenediaminetetraacetic acid, free acid) in the body app

Look up products containing edta (ethylenediaminetetraacetic acid, free acid), compare to alternatives, and explore the full data record.

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Sources (1)
  1. — expert_curation

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for veterinary, medical, legal, or regulatory advice. Why we built ALETHEIA →