Diethylhexyl butamido triazone on your skin: a safety profile

What is diethylhexyl butamido triazone?

The IUPAC name is 1,3,5-triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-ethylhexyl)-.

Also known as: 1,3,5-triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-ethylhexyl)-, Iscotrizinol, DHHB, Uvasorb HEB.

IUPAC name

1,3,5-triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-ethylhexyl)-

CAS number

154702-15-5

Molecular formula

C41H61N3O3

Molecular weight

647.96 g/mol

SMILES

CC(=O)NC1=CC2=C(C=C(N=C2C=C1)C=CC3=CC=C(O3)[N+](=O)[O-])NC(=O)C

PubChem CID

6433209

Regulatory consensus

2 regulatory and scientific bodies have classified Diethylhexyl butamido triazone. The classifications differ — that's the data.

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter diethylhexyl butamido triazone

• water_resistant_sunscreen
• premium_sunscreen
• facial_sunscreen
• sports_sunscreen

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Diethylhexyl butamido triazone:

• Mineral UV filters (zinc oxide, titanium dioxide) — no systemic absorption
  Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
  Relative cost: 1.2-2×
• Newer-generation organic filters with lower skin penetration (e.g., bisoctrizole)
  Trade-offs: Alternative approach; specific tradeoffs depend on application context, scale, and regulatory requirements. Full hazard assessment of alternative recommended before adoption to avoid regrettable substitution.
  Relative cost: 2-5× conventional
• UPF-rated clothing and physical sun protection
  Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
  Relative cost: 1.2-2×

Frequently asked questions