Cocamidopropyl hydroxysultaine on your skin: a safety profile

What is cocamidopropyl hydroxysultaine?

The IUPAC name is 3-(cocamido)-1-hydroxypropane-1-sulfonate.

Also known as: 3-(cocamido)-1-hydroxypropane-1-sulfonate, CAPHS, NS00120232.

IUPAC name

3-(cocamido)-1-hydroxypropane-1-sulfonate

CAS number

68139-30-0

Molecular formula

C8-C18H35-51NO4S (mixture)

Molecular weight

382.6 g/mol

SMILES

CC(=CC1=CC=C(C=C1)S(=O)(=O)C)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C

PubChem CID

71314

Regulatory consensus

1 regulatory bodyhas classified Cocamidopropyl hydroxysultaine.

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter cocamidopropyl hydroxysultaine

• baby shampoo
• sensitive skin cleansers
• facial wash
• gentle body wash

Safer alternatives

Lower-risk approaches that achieve a similar outcome to Cocamidopropyl hydroxysultaine:

• Alkyl polyglucosides (APGs) — plant-derived, very mild (e.g., decyl glucoside)
  Trade-offs: Consumer preference for 'natural' label; many natural fragrance compounds are potent allergens (limonene, linalool, eugenol); 'natural' ≠ 'safe'; often more expensive than synthetic equivalents.
  Relative cost: 2-5× conventional
• Amino acid-based surfactants (e.g., sodium lauroyl glutamate, sodium cocoyl glycinate)
  Trade-offs: Extremely mild (pH 5.5-6.5); biodegradable; derived from amino acids and fatty acids; premium ingredient cost; excellent consumer perception; lower foam volume than sulfate surfactants.
  Relative cost: 1.2-2×
• Sodium cocoyl isethionate (SCI) — low irritation potential, solid surfactant
  Trade-offs: Alternative surfactant; performance characteristics (foaming, emulsification, wetting) vary; biodegradability and aquatic toxicity should be assessed; formulation adjustment may be needed.
  Relative cost: 1.2-2×
• Amphoteric surfactants (e.g., cocamidopropyl betaine) — milder than anionic types
  Trade-offs: Removes 95-99% of dissolved contaminants including metals, PFAS, nitrates; wastes 2-4 gallons per gallon produced (improving with newer systems); removes beneficial minerals; $0.05-0.25/gallon; requires pre-treatment for longevity.
  Relative cost: 1.2-2×

Frequently asked questions